GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs7927771 | 1 | rs11039255 | chr11:47495746 | MADD | chr11:47290927-47351582:+ | 0.13 | 4.25 | 2.37E-5 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs11039255 | chr11:47495746 | MYBPC3 | chr11:47352958-47374253:- | -0.15 | -4.53 | 6.45E-6 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs11039390 | chr11:47796295 | MADD | chr11:47290927-47351582:+ | 0.15 | 4.51 | 7.28E-6 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs11039390 | chr11:47796295 | MYBPC3 | chr11:47352958-47374253:- | -0.14 | -4.29 | 1.98E-5 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs11039412 | chr11:47841581 | MADD | chr11:47290927-47351582:+ | 0.15 | 4.5 | 7.53E-6 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs11039412 | chr11:47841581 | MYBPC3 | chr11:47352958-47374253:- | -0.14 | -4.11 | 4.28E-5 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs11039426 | chr11:47863119 | MADD | chr11:47290927-47351582:+ | 0.15 | 4.51 | 7.22E-6 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs11039426 | chr11:47863119 | MYBPC3 | chr11:47352958-47374253:- | -0.14 | -4.13 | 3.93E-5 | Subjective well-being |
| BRCA | cis | rs3858526 | 1 | rs11039787 | chr11:5965611 | UBQLNL | chr11:5535624-5537956:- | 0.15 | 3.4 | 0.000692 | DNA methylation (variation) |
| BRCA | cis | rs2555155 | 1 | rs11040899 | chr11:6520015 | DNHD1 | chr11:6518526-6593252:+ | -0.11 | -3.38 | 0.000738 | DNA methylation (variation) |
| BRCA | cis | rs2555155 | 1 | rs11040899 | chr11:6520015 | TPP1 | chr11:6633997-6640692:- | -0.11 | -3.42 | 0.00065 | DNA methylation (variation) |
| BRCA | cis | rs718314 | 1 | rs11048457 | chr12:26463174 | BHLHE41 | chr12:26272961-26278003:- | -0.13 | -3.76 | 0.000178 | Waist-hip ratio;Renal cell carcinoma |
| BRCA | cis | rs718314 | 1 | rs11048457 | chr12:26463174 | SSPN | chr12:26348269-26405853:+ | -0.11 | -3.59 | 0.000344 | Waist-hip ratio;Renal cell carcinoma |
| BRCA | cis | rs2638953 | 1 | rs11049516 | chr12:28452582 | CCDC91 | chr12:28332210-28703098:+ | 0.16 | 4.06 | 5.17E-5 | Height |
| BRCA | cis | rs2638953 | 1 | rs11049532 | chr12:28476912 | CCDC91 | chr12:28332210-28703098:+ | 0.16 | 4.15 | 3.64E-5 | Height |